Synthesis of novel iodinated derivatives of nonoxynol-9 and their bioavailability in rats

The absorption and distribution of iodinated derivatives of nonoxynol-9. after vaginal administration in rats, were compared with results reported for [C-14] nonoxynol-9. Mono-iodinated nonoxynol-9 was synthesized in addition to the radiolabeled derivative incorporating iodide-125 ([I-125]). Six hours after closing. test rats were euthanized and selected tissues were excised and assessed for radioactivity. Levels of radioactive markers in the reproductive system were substantial for both [C-14] and [I-125]. It was concluded that [I-125] mono-iodinated nonoxynol-9 and [C-14] nonoxynol-9 possessed similar bioavailability. (C) 2002 Elsevier Science Inc. All rights reserved.