Direct asymmetric aldol reactions in brine using novel sulfonamide catalyst

被引：37

作者：

Miura, Tsuyoshi ^{[1
]}

Yasaku, Yumi ^{[1
]}

Koyata, Naka ^{[1
]}

Murakami, Yasuoki ^{[1
]}

Imai, Nobuyuki ^{[1
]}

机构：

[1] Chiba Inst Sci, Fac Pharm, Chiba 2880025, Japan

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 22期

基金：

日本学术振兴会;

关键词：

WATER-COMPATIBLE ORGANOCATALYSTS; DIRECT SYN-ALDOL; ENANTIOSELECTIVE CYCLOPROPANATION; ORGANIC-REACTIONS; AMINO-ACID; DISULFONAMIDE LIGAND; ALIPHATIC-KETONES; HIGHLY EFFICIENT; SMALL PEPTIDES; AQUEOUS-MEDIA;

D O I：

10.1016/j.tetlet.2009.03.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct asymmetric aldol reactions of aldehydes with ketones in the presence of a catalytic amount of sulfonamide 4 and trifluoroacetic acid afforded the corresponding anti-aldol products in moderate to excellent yields with 85-93% ee. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2632 / 2635

页数：4

共 47 条

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