Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection

被引：22

作者：

Gaudy, C

Moreau, A

Brunet, S

Descamps, JM

Deleplanque, P

Brand, D

Barin, F ^{[1
]}

机构：

[1] CHU Bretonneau, Virol Lab, Ctr Natl Reference VIH, Equipe Associee 3250, F-37044 Tours, France

[2] Ctr Hosp, Niort, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2004年 / 42卷 / 06期

关键词：

D O I：

10.1128/JCM.42.6.2847-2849.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.

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页码：2847 / 2849

页数：3

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