The role of heparan sulphate in inflammation

被引：383

作者：

Parish, Christopher R. ^{[1
]}

机构：

[1] Australian Natl Univ, Div Immunol & Genet, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nri1918

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The polysaccharide heparan sulphate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. Heparan sulphate has marked sequence diversity that allows it to specifically interact with many proteins. This Review focuses on the multiple roles of heparan sulphate in inflammatory responses and, in particular, on its participation in almost every stage of leukocyte transmigration through the blood-vessel wall. Heparan sulphate is involved in the initial adhesion of leukocytes to the inflamed endothelium, the subsequent chemokine-mediated transmigration through the vessel wall and the establishment of both acute and chronic inflammatory reactions.

引用

收藏

页码：633 / 643

页数：11

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