1,2,4-Trioxepanes: Redox-cleavable protection for carbonyl groups

被引：22

作者：

Ahmed, A ^{[1
]}

Dussault, PH ^{[1
]}

机构：

[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 20期

关键词：

D O I：

10.1021/ol048484h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,4-trioxepanes, readily prepared and easily handled derivatives of aldehydes and ketones, are stable to a variety of synthetic conditions and yet easily deblocked with Zn/HOAc or Mg/MeOH to regenerate the parent carbonyl. Trioxepanes may provide an alternative to 1,3-dithianes for acid-stable protection of carbonyl groups.

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页码：3609 / 3611

页数：3

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