Large-scale analysis of pseudogenes in the human genome

被引：124

作者：

Zhang, ZL ^{[1
]}

Gerstein, M ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.gde.2004.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pseudogenes are considered as genomic fossils: disabled copies of functional genes that were once active in the ancient genome. Recently, whole-genome computational approaches have revealed thousands of pseudogenes in the genomes of the human and other eukaryotes. Identification of these pseudogenes can improve the accuracy of gene annotation. It also offers new insight on the evolutionary history and the stability of the genome as a whole.

引用

页码：328 / 335

页数：8

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