Large-scale analysis of pseudogenes in the human genome

被引：124

作者：

Zhang, ZL ^{[1
]}

Gerstein, M ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.gde.2004.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pseudogenes are considered as genomic fossils: disabled copies of functional genes that were once active in the ancient genome. Recently, whole-genome computational approaches have revealed thousands of pseudogenes in the genomes of the human and other eukaryotes. Identification of these pseudogenes can improve the accuracy of gene annotation. It also offers new insight on the evolutionary history and the stability of the genome as a whole.

引用

页码：328 / 335

页数：8

共 58 条

[11] pANT: A method for the pairwise assessment of nonfunctionalization times of processed pseudogenes [J].

Fleishman, SJ ;

Dagan, T ;

Graur, D .

MOLECULAR BIOLOGY AND EVOLUTION, 2003, 20 (11) :1876-1880

[12] Transcriptional analysis of the PTEN/MMAC1 pseudogene, ΨPTEN [J].

Fujii, GH ;

Morimoto, AM ;

Berson, AE ;

Bolen, JB .

ONCOGENE, 1999, 18 (09) :1765-1769

[13] The complete human olfactory subgenome [J].

Glusman, G ;

Yanai, I ;

Rubin, I ;

Lancet, D .

GENOME RESEARCH, 2001, 11 (05) :685-702

[14] Nature and structure of human genes that generate retropseudogenes [J].

Gonçalves, I ;

Duret, L ;

Mouchiroud, D .

GENOME RESEARCH, 2000, 10 (05) :672-678

[15] DELETIONS IN PROCESSED PSEUDOGENES ACCUMULATE FASTER IN RODENTS THAN IN HUMANS [J].

GRAUR, D ;

SHUALI, Y ;

LI, WH .

JOURNAL OF MOLECULAR EVOLUTION, 1989, 28 (04) :279-285

[16] Association between p47phox pseudogenes and inflammatory bowel disease [J].

Harbord, M ;

Hankin, A ;

Bloom, S ;

Mitchison, H .

BLOOD, 2003, 101 (08) :3337-3337

[17] RT-PCR for the pseudogene-free amplification of the glyceraldehyde-3-phosphate dehydrogenase gene (gapd) [J].

Harper, LV ;

Hilton, AC ;

Jones, AF .

MOLECULAR AND CELLULAR PROBES, 2003, 17 (05) :261-265

[18] A small reservoir of disabled ORFs in the yeast genome and its implications for the dynamics of proteome evolution [J].

Harrison, P ;

Kumar, A ;

Lan, N ;

Echols, N ;

Snyder, M ;

Gerstein, M .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 316 (03) :409-419

[19] Identification of pseudogenes in the Drosophila melanogaster genome [J].

Harrison, PM ;

Milburn, D ;

Zhang, Z ;

Bertone, P ;

Gerstein, M .

NUCLEIC ACIDS RESEARCH, 2003, 31 (03) :1033-1037

[20] Molecular fossils in the human genome: Identification and analysis of the pseudogenes in chromosomes 21 and 22 [J].

Harrison, PM ;

Hegyi, H ;

Balasubramanian, S ;

Luscombe, NM ;

Bertone, P ;

Echols, N ;

Johnson, T ;

Gerstein, M .

GENOME RESEARCH, 2002, 12 (02) :272-280

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