Tramtrack co-operates to prevent inappropriate neural development in Drosophila

被引:36
作者
Badenhorst, P [1 ]
Finch, JT [1 ]
Travers, AA [1 ]
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
tramtrack; BTB domain; Drosophila; neurogenesis; peripheral nervous system; Achaete-Scute complex;
D O I
10.1016/S0925-4773(02)00183-1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Each sensory organ of the Drosophila peripheral nervous system is derived from a single sensory organ precursor cell (SOP). These originate in territories defined by expression of the proneural genes of the Achaete-Scute complex (AS-C). Formation of ectopic sensilla outside these regions is prevented by transcriptional repression of proneural genes. We demonstrate that the BTB/POZ-domain transcriptional repressor Tramtrack (Ttk) co-operates in this repression. Ttk is expressed ubiquitously, except in proneural clusters and SOPs. Ttk over-expression represses proneural genes and sensilla formation. Loss of Ttk enhances bristle-promoting mutants. Using neural repression as an assay, we dissected functional domains of Ttk, confirming the importance of the bric-a-brac-tramtrack-broad complex (BTB) motif. We show that the Ttk BTB domain is a protein-protein interaction motif mediating tetramer formation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
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页码:87 / 101
页数:15
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