Thymopentin in solid lipid nanoparticles

被引：86

作者：

Morel, S ^{[1
]}

Ugazio, E ^{[1
]}

Cavalli, R ^{[1
]}

Gasco, MR ^{[1
]}

机构：

[1] DIPARTIMENTO SCI & TECNOL FARM,I-10125 TURIN,ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 132卷 / 1-2期

关键词：

thymopentin; warm O/W and W/O/W microemulsions; solid lipid nanoparticles; polypeptides;

D O I：

10.1016/0378-5173(95)04388-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pentapeptide thymopentin was englobed in solid lipid nanoparticles prepared from warm microemulsions following two different methods: from O/W microemulsion by forming the more lipophilic ion-pair with hexadecylphosphate, and from W/O/W microemulsion by dissolving the pentapeptide in the aqueous internal phase. The incorporation of the hydrophilic drug was 5.2% and 1.7% respectively; in both cases, the in vitro release of thymopentin from the solid lipid nanoparticles followed a pseudo-zero-order kinetics.

引用

页码：259 / 261

页数：3

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