Effects of the olive, extra virgin olive and canola oils on cisplatin-induced clastogenesis in Wistar rats

Cisplatin is one of the mostly used antineoplastic drugs in the treatment of cancer, but its clastogenic potential has become of great interest. In patients treated with long-term cisplatin, genetic damage can be observed during chemotherapy or many years later. The aim of this study was to investigate the possible anticlastogenic effect of pretreatment with olive, extra virgin olive, canola or corn oils on cisplatin-induced chromosomal aberrations in Wistar rat bone marrow cells. The animals received pretreatment with a single dose of vegetable oils (5 ml/kg b.w.) by gavage before cisplatin i.p. (5 mg/kg b.w.), and were sacrificed 24 h after cisplatin injection. The pretreatment with a single dose of olive, extra virgin olive and canola oils caused a statistically significant decrease in the total of chromosomal aberrations and abnormal metaphases induced by cisplatin when compared with the groups treated with cisplatin alone. The possible explanation for the anticlastogenic effects observed in the pretreatment with olive, extra virgin olive and canola oils is ascribed to the oil contents. In conclusion, from the findings we suggest that these oils have some antioxidant effect, and the anticlastogenesis mechanisms of these oils need to be explored further before their use during cisplatin chemotherapy. (C) 2004 Elsevier Ltd. All rights reserved.