Cytochrome c release from mitochondria:: all or nothing

被引：295

作者：

Martinou, JC

Desagher, S

Antonsson, B

机构：

[1] Serono Pharmaceut Res Inst, CH-1228 Plan Les Quates, Switzerland

[2] CNRS, UPR 9023 CCIPE, F-34094 Montpellier 5, France

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1038/35004069

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the process of apoptosis, cytochrome c is released from mitochondria into the cytosol where it helps to activate the caspases, a family of killer proteases. The release of cytochrome c is a rapid, complete and kinetically invariant event.

引用

页码：E41 / E43

页数：3

共 11 条

[1] Inhibition of Bax channel-forming activity by Bcl-2
Antonsson, B
Conti, F
Ciavatta, A
Montessuit, S
Lewis, S
Martinou, I
Bernasconi, L
Bernard, A
Mermod, JJ
Mazzei, G
Maundrell, K
Gambale, F
Sadoul, R
Martinou, JC
[J]. SCIENCE, 1997, 277 (5324) : 370 - 372
[2] Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations
Basañez, G
Nechushtan, A
Drozhinin, O
Chanturiya, A
Choe, E
Tutt, S
Wood, KA
Hsu, YT
Zimmerberg, J
Youle, RJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) : 5492 - 5497
[3] Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions
Eskes, R
Antonsson, B
Osen-Sand, A
Montessuit, S
Richter, C
Sadoul, R
Mazzei, G
Nichols, A
Martinou, JC
[J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (01) : 217 - 224
[4] The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
Goldstein, JC
Waterhouse, NJ
Juin, P
Evan, GI
Green, DR
[J]. NATURE CELL BIOLOGY, 2000, 2 (03) : 156 - 162
[5] Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells
Heiskanen, KM
Bhat, MB
Wang, HW
Ma, JJ
Nieminen, AL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (09) : 5654 - 5658
[6] Bax directly induces release of cytochrome c from isolated mitochondria
Jürgensmeier, JM
Xie, ZH
Deveraux, Q
Ellerby, L
Bredesen, D
Reed, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) : 4997 - 5002
[7] The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
Kluck, RM
Esposti, MD
Perkins, G
Renken, C
Kuwana, T
Bossy-Wetzel, E
Goldberg, M
Allen, T
Barber, MJ
Green, DR
Newmeyer, DD
[J]. JOURNAL OF CELL BIOLOGY, 1999, 147 (04) : 809 - 822
[8] Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
Marzo, I
Brenner, C
Zamzami, N
Jürgensmeier, JM
Susin, SA
Vieira, HLA
Prévost, MC
Xie, ZH
Matsuyama, S
Reed, JC
Kroemer, G
[J]. SCIENCE, 1998, 281 (5385) : 2027 - 2031
[9] Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
Schlesinger, PH
Gross, A
Yin, XM
Yamamoto, K
Saito, M
Waksman, G
Korsmeyer, SJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) : 11357 - 11362
[10] Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
Shimizu, S
Narita, M
Tsujimoto, Y
[J]. NATURE, 1999, 399 (6735) : 483 - 487

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