Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids

被引：118

作者：

Schaer, DJ

Boretti, FS

Schoedon, G

Schaffner, A

机构：

[1] Univ Zurich Hosp, Med Klin B, Dept Internal Med, Zurich, Switzerland

[2] Univ Zurich, Dept Vet Internal Med, CH-8006 Zurich, Switzerland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 119卷 / 01期

关键词：

CD163; macrophage-haemoglobin scavenger receptor; glucocorticoids; haemolysis; haptoglobin;

D O I：

10.1046/j.1365-2141.2002.03790.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Highly efficient systems remove toxic and proinflammatory haemoglobin (Hb) from the circulation and local sites of tissue damage. Macrophages are major Hb-clearing cells; CD163 was recently recognized as the specific haemoglobin-haptoglobin scavenger receptor (HSR). We show that dexamethasone strongly induced the specific uptake of haemoglobin-haptoglobin complexes, CD163 mRNA transcription (13-fold) and cell surface expression (10-fold) by human macrophages. In contrast, the TH2-cytokine interleukin 4 (IL-4) completely suppressed functional CD163 expression. The range of functional receptor modulation reached a factor of 100 after 4 h of macrophage-ligand interaction. Based on these results, we propose the augmentation of Hb clearance as a novel anti-inflammatory action of glucocorticoids.

引用

页码：239 / 243

页数：5