A novel metal iodide promoted three-component synthesis of substituted pyrrolidines

被引：131

作者：

Bertozzi, F ^{[1
]}

Gustafsson, M ^{[1
]}

Olsson, R ^{[1
]}

机构：

[1] ACADIA Pharmaceut AS, Discovery Chem, DK-2600 Glostrup, Denmark

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 18期

关键词：

D O I：

10.1021/ol0264814

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new one-pot procedure for the synthesis of substituted pyrrolidine derivatives with commercially available cyclopropyl ketones, aldehydes, and amines by a metal iodide promoted three-component reaction was developed.

引用

页码：3147 / 3150

页数：4

共 33 条

[1] A novel use of Grubbs' carbene. Application to the catalytic deprotection of tertiary allylamines
Alcaide, B
Almendros, P
Alonso, JM
Aly, MF
[J]. ORGANIC LETTERS, 2001, 3 (23) : 3781 - 3784
[2] Alper PB, 1999, ANGEW CHEM INT EDIT, V38, P3186, DOI 10.1002/(SICI)1521-3773(19991102)38:21<3186::AID-ANIE3186>3.3.CO
[3] 2-5
[4] Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists
Bhagwat, SS
Gude, C
Chan, K
[J]. TETRAHEDRON LETTERS, 1996, 37 (27) : 4627 - 4630
[5] Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO
[6] 2-A
[7] Biginelli P., 1891, BERICHTE DTSCH CHEM, V24, P1317, DOI [DOI 10.1002/CBER.189102401228, 10.1002/cber.189102401228]
[8] BILLMANN JH, 1952, J ORG CHEM, V23, P535
[9] Cushman D W, 1980, Prog Med Chem, V17, P41, DOI 10.1016/S0079-6468(08)70157-7
[10] ELECTROPHILIC CYCLOPROPANES IN ORGANIC-SYNTHESIS
DANISHEFSKY, S
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1979, 12 (02) : 66 - 72

← 1 2 3 4 →