Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists

被引：15

作者：

Bhagwat, SS ^{[1
]}

Gude, C ^{[1
]}

Chan, K ^{[1
]}

机构：

[1] CIBA GEIGY CORP,DIV PHARMACEUT,RES DEPT,SUMMIT,NJ 07901

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期

关键词：

D O I：

10.1016/0040-4039(96)00919-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure pyrrolidinones were synthesized as endothelin receptor antagonists. A [2+2] cycloaddition of an imine and an enantiomerically pure acid chloride gave two diastereomeric beta-lactams which were separated and rearranged to give the enantiomerically pure pyrrolidinones which could be reduced to give the corresponding pyrrolidines. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4627 / 4630

页数：4

共 3 条

[1] TRANS DIASTEREOSELECTIVE SYNTHESIS OF 3-ALKYL SUBSTITUTED BETA-LACTAMS VIA THE ACID CHLORIDE-IMINE REACTION OF NONACTIVATED ACID-CHLORIDES
BROWNE, M
BURNETT, DA
CAPLEN, MA
CHEN, LY
CLADER, JW
DOMALSKI, M
DUGAR, S
PUSHPAVANAM, P
SHER, R
VACCARO, W
VIZIANO, M
ZHAO, HR
[J]. TETRAHEDRON LETTERS, 1995, 36 (15) : 2555 - 2558
[2] GEORG GI, 1992, ORGANIC CHEM BETA LA, P295
[3] ENDOTHELIN RECEPTOR ANTAGONISTS
WARNER, TD
[J]. CARDIOVASCULAR DRUG REVIEWS, 1994, 12 (02): : 105 - 122

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