The relationship between chromosome structure and function at a human telomeric region

被引：126

作者：

Flint, J

Thomas, K

Micklem, G

Raynham, H

Clark, K

Doggett, NA

King, A

Higgs, DR

机构：

[1] JOHN RADCLIFFE HOSP, INST MOL MED, MRC, MOL HAEMATOL UNIT, OXFORD OX3 9DU, ENGLAND

[2] SANGER CTR, CAMBRIDGE CB10 1RQ, ENGLAND

[3] LOS ALAMOS NATL LAB, DIV LIFE SCI, LOS ALAMOS, NM 87545 USA

来源：

NATURE GENETICS | 1997年 / 15卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng0397-252

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have sequenced a contiguous 284,495-bp segment of DNA extending from the terminal (TTAGGC)(n) repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and extend analysis of the primary sequence, we have characterized mRNA transcripts, patterns of DNA methylation and DNase I sensitivity. Together with previous data these studies describe in detail the structural and functional organization of a human telomeric region.

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页码：252 / 257

页数：6

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