Use of 1,2-dichloro 4,5-dicyanoquinone (DDQ) for cleavage of the 2-naphthylmethyl (NAP) group

被引：170

作者：

Xia, J ^{[1
]}

Abbas, SA ^{[1
]}

Locke, RD ^{[1
]}

Piskorz, CF ^{[1
]}

Alderfer, JL ^{[1
]}

Matta, KL ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)02046-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 2-naphthylmethyl (NAP) group is a versatile group for protection of hydroxyl functions. It is stable to 4% TFA in CHCl3, hot 80% HOAc-H2O, SnCl2-AgOTf and HCl-EtOH, but it can readily be removed with DDQ in CH2Cl2. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：169 / 173

页数：5

共 24 条

[1]

Bernardi A, 1999, EUR J ORG CHEM, V1999, P1311, DOI 10.1002/(SICI)1099-0690(199906)1999:6<1311::AID-EJOC1311>3.0.CO

[2]

2-W

[3]

BESSODES M, 1988, SYNTHESIS-STUTTGART, P560

[4] Regioselective deprotection of p-methoxybenzyl ethers of furanose derivatives [J].