Reversal learning in Parkinson's disease depends on medication status and outcome valence

被引:226
作者
Cools, Roshan
Altamirano, Lee
D'Esposito, Mark
机构
[1] Univ Cambridge, Behav & Clin Neurosci Inst, Dept Expt Psychol, Cambridge CB2 3EB, England
[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
关键词
dopamine; cognition; reward; punishment; flexibility; ventral striatum;
D O I
10.1016/j.neuropsychologia.2006.03.030
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We investigated the role of dopamine in distinct forms of reversal shifting by comparing two groups of patients with mild Parkinson's disease (PD), one ON and one OFF their normal dopaminergic medication. In accordance with our previous work, patients ON medication exhibited impaired reversal shifting relative to patients OFF medication. The present results extend previous studies by showing that the medication-induced deficit on reversal shifting was restricted to conditions where reversals were signaled by unexpected punishment. By contrast, patients ON medication performed as well as patients OFF medication and controls when the reversal was signaled by unexpected reward. The medication-induced deficit was particularly pronounced in patients on the dopamine D3 receptor agonist pramipexole. These data indicate that dopaminergic medication in PD impairs reversal shifting depending on the motivational valence of unexpected outcomes. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1663 / 1673
页数:11
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