The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet

被引：46

作者：

Negis, Yesim

Aytan, Nurgul

Ozer, Nesrin

Ogru, Esra

Libinaki, Roksan

Gianello, Robert

Azzi, Angelo

Zingg, Jean-Marc

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, Bern, Switzerland

[2] Marmara Univ, Fac Med, Dept Biochem, TR-81326 Istanbul, Turkey

[3] Phosphagen Ltd, Melbourne, Vic, Australia

[4] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2006年 / 450卷 / 01期

关键词：

tocopherol; antioxidants; atherosclerosis; tocopheryl phosphate;

D O I：

10.1016/j.abb.2006.02.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of tocopheryl phosphate on atherosclerosis progression has been studied in rabbits, fed with a 2% cholesterol diet and compared with an equivalent amount of alpha-tocopheryl acetate. The results show that the atherosclerotic-preventing effect of the phosphate derivative was more pronounced than that of the acetate derivative. alpha-Tocopheryl phosphate was also more potent in diminishing the expression of CD36 than the acetate derivative. (c) 2006 Elsevier Inc. All rights reserved.

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收藏

页码：63 / 66

页数：4

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