Nuclear reprogramming and pluripotency

被引：344

作者：

Hochedlinger, Konrad

Jaenisch, Rudolf ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02142 USA

[2] Whitehead Inst, Cambridge, MA 02142 USA

[3] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE | 2006年 / 441卷 / 7097期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature04955

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.

引用

页码：1061 / 1067

页数：7

共 100 条

[41] Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei
Humphreys, D
Eggan, K
Akutsu, H
Friedman, A
Hochedlinger, K
Yanagimachi, R
Lander, ES
Golub, TR
Jaenisch, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) : 12889 - 12894
[42] Generation of cloned mice by direct nuclear transfer from natural killer T cells
Inoue, K
Wakao, H
Ogonuki, N
Miki, H
Seino, KI
Nambu-Wakao, R
Noda, S
Miyoshi, H
Koseki, H
Taniguchi, M
Ogura, A
[J]. CURRENT BIOLOGY, 2005, 15 (12) : 1114 - 1118
[43] Inefficient reprogramming of the hematopoietic stem cell genome following nuclear transfer
Inoue, Kimiko
Ogonuki, Narumi
Miki, Hiromi
Hirose, Michiko
Noda, Shinichi
Kim, Jin-Moon
Aoki, Fugaku
Miyoshi, Hiroyuki
Ogura, Atsuo
[J]. JOURNAL OF CELL SCIENCE, 2006, 119 (10) : 1985 - 1991
[44] Human cloning - The science and ethics of nuclear transportation
Jaenisch, R
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (27) : 2787 - 2791
[45] Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Yuehua
Jahagirdar, Balkrishna N.
Reinhardt, R. Lee
Schwartz, Robert E.
Keene, C. Dirk
Ortiz-Gonzalez, Xilma R.
Reyes, Morayma
Lenvik, Todd
Lund, Troy
Blackstad, Mark
Du, Jingbo
Aldrich, Sara
Lisberg, Aaron
Low, Walter C.
Lergaespada, David A.
Verfaillie, Catherine M.
[J]. Nature, 2002, 418 (6893) : 41 - 49
[46] Generation of pluripotent stem cells from neonatal mouse testis
Kanatsu-Shinohara, M
Inoue, K
Lee, J
Yoshimoto, M
Ogonuki, N
Miki, H
Baba, S
Kato, T
Kazuki, Y
Toyokuni, S
Toyoshima, M
Niwa, O
Oshimura, M
Heike, T
Nakahata, T
Ishino, F
Ogura, A
Shinohara, T
[J]. CELL, 2004, 119 (07) : 1001 - 1012
[47] Oct4 is required for primordial germ cell survival
Kehler, J
Tolkunova, E
Koschorz, B
Pesce, M
Gentile, L
Boiani, M
Lomelí, H
Nagy, A
McLaughlin, KJ
Schöler, HR
Tomilin, A
[J]. EMBO REPORTS, 2004, 5 (11) : 1078 - 1083
[48] Kennedy Donald, 2006, Science, V311, P335
[49] Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI
Kikyo, N
Wade, PA
Guschin, D
Ge, H
Wolffe, AP
[J]. SCIENCE, 2000, 289 (5488) : 2360 - 2362
[50] A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
Kögler, G
Sensken, S
Airey, JA
Trapp, T
Müschen, M
Feldhahn, N
Liedtke, S
Sorg, RV
Fischer, J
Rosenbaum, C
Greschat, S
Knipper, A
Bender, J
Degistirici, O
Gao, JZ
Caplan, AI
Colletti, E
Almeida-Porada, G
Müller, HW
Zanjani, E
Wernet, P
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (02) : 123 - 135

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