Effects of cerebrovascular challenges on plasma endothelin

被引：27

作者：

Jordan, W

Decker, M

Kamrowski, H

Brunner, E

Ehrenreich, H

Hajak, G

机构：

[1] Univ Gottingen, Dept Psychiat & Psychotherapy, Psychiat Klin, D-37075 Gottingen, Germany

[2] Max Planck Inst Expt Med, D-37075 Gottingen, Germany

[3] Univ Gottingen, Dept Med Stat, D-37075 Gottingen, Germany

[4] Univ Gottingen, Dept Neurol, D-37075 Gottingen, Germany

[5] Univ Regensburg, Dept Psychiat & Psychotherapy, D-8400 Regensburg, Germany

来源：

NEUROSCIENCE RESEARCH | 2002年 / 43卷 / 02期

关键词：

CO2; inhalation; hypercapnia; hypocapnia; cerebral blood flow velocity; cerebral hemodynamics; immunoreactive endothelin-1 concentration; transcranial Doppler ultrasonography; TCD;

D O I：

10.1016/S0168-0102(02)00022-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Plasma endothelin elevations have been associated with cerebrovascular pathology. Mechanisms of stimulation, however, are unknown. Therefore, in healthy subjects a marked physiological cerebrovascular response was experimentally provoked by hypercapnia, hypocapnia, and alternating capneic conditions. During these challenges plasma immunoreactive-endothelin-1 (ir-ET-1) concentrations were determined using a radioimmunassay. Physiological effects were continuously recorded for pCO(2), cerebral blood flow velocity, pulse frequency, and arterial blood pressure. No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-I levels. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：127 / 134

页数：8

共 30 条

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