How obesity causes diabetes in Zucker diabetic fatty rats

被引：105

作者：

Unger, RH

机构：

[1] Center for Diabetes Research, Univ. of Texas Southwestern Med. C., Dallas

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1997年 / 8卷 / 07期

关键词：

D O I：

10.1016/S1043-2760(97)00094-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, ave I reviewed. In ZDF rats, a mutation in the leptin receptor OB-R, is associated with leptin resistance obesity and increased fat content of islets, Exaggerated nitric oxide (NO) generation, attributed to high intracellular levels of long-chain fatty acids, impairs beta-cell function and prevents their compensation for obesity-induced diabetes. The resulting diabetic hyperglycemia can be completely prevented by agents that inhibit NO production. (C) 1997, Elsevier Science Inc.

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页码：276 / 282

页数：7

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