Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

被引：115

作者：

Byrareddy, Siddappa N. ^{[1
]}

Kallam, Brianne ^{[1
]}

Arthos, James ^{[2
]}

Cicala, Claudia ^{[2
]}

Nawaz, Fatima ^{[2
]}

Hiatt, Joseph ^{[2
]}

Kersh, Ellen N. ^{[3
]}

McNicholl, Janet M. ^{[3
]}

Hanson, Debra ^{[3
]}

Reimann, Keith A. ^{[4
]}

Brameier, Markus ^{[5
]}

Walter, Lutz ^{[5
]}

Rogers, Kenneth ^{[6
]}

Mayne, Ann E. ^{[1
]}

Dunbar, Paul ^{[1
]}

Villinger, Tara ^{[1
]}

Little, Dawn ^{[1
]}

Parslow, Tristram G. ^{[1
]}

Santangelo, Philip J. ^{[7
,8
]}

Villinger, Francois ^{[1
,6
]}

Fauci, Anthony S. ^{[2
]}

Ansari, Aftab A. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[2] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[3] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA

[4] Univ Massachusetts, Sch Med, Mass Biol, Boston, MA 02125 USA

[5] German Primate Ctr, Leibniz Inst Primate Res, Primate Genet Lab, Gottingen, Germany

[6] Emory Univ, Yerkes Natl Primate Res Ctr, Div Microbiol & Immunol, Atlanta, GA 30322 USA

[7] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[8] Emory Univ, Atlanta, GA 30322 USA

来源：

NATURE MEDICINE | 2014年 / 20卷 / 12期

关键词：

T-CELL SUBSET; MAINTENANCE THERAPY; IMMUNE ACTIVATION; ALPHA-4-BETA-7; VEDOLIZUMAB; INDUCTION; DEPLETION; RECEPTOR; TRACT; CD4;

D O I：

10.1038/nm.3715

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha(4)beta(7) integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-alpha(4)beta(7) monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIVmac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4(+) T cell numbers were maintained in both the blood and the GALT. Thus, targeting alpha(4)beta(7) reduces mucosal transmission of Sly in macaques.

引用

页码：1397 / 1400

页数：4

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