Changes in urine 8-hydroxydeoxyguanosine levels of super-marathon runners during a four-day race period

被引:73
作者
Radák, Z
Pucsuk, J
Boros, S
Josfai, L
Taylor, AW
机构
[1] Hungarian Univ Phys Educ, Lab Exercise Physiol, Budapest, Hungary
[2] Natl Inst Sport Med, Res Lab, Budapest, Hungary
[3] Univ Western Ontario, Fac Hlth Sci, London, ON N6A 3K7, Canada
[4] Univ Western Ontario, Fac Med, London, ON N6A 3K7, Canada
[5] Univ Western Ontario, Fac Dent, London, ON N6A 3K7, Canada
关键词
prolonged exercise; DNA damage; oxidative stress; free radicals; adaptation;
D O I
10.1016/S0024-3205(00)00499-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We have determined the urinary 8-hydroxydeoxyguanosine (8-OHdG) levels of five well trained supra-marathon runners during a four-day race. The daily running distances of the four-day race were the following; 93 km, 120 km, 56 lan and 59 km, respectively. Pre-race and post-race urine samples were collected on each day and analyzed by a monoclonal antibody technique. The urinary 8-OHdG content increased significantly on the first day and tended to decrease from the third day. By the fourth day 8-OHdG content was significantly less than measured on the first three days. The serum creatine kinase activity changed in a similar fashion, showing a large increase (P<0.001) up to the third day when it decreased significantly from the peak value (P<0.05). We conclude that extreme physical exercise causes oxidative DNA damage to well trained athletes. However, repeated extreme exercise-induced oxidative stress does not propagate on increase of urinary 8-OHdG, but rather causes an adaptation leading to normalization of oxidative DNA damage.
引用
收藏
页码:1763 / 1767
页数:5
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