International Union of Pharmacology. LXVI. Orphan nuclear receptors

被引:175
作者
Benoit, Gerard
Cooney, Austin
Giguere, Vincent
Ingraham, Holly
Lazar, Mitch
Muscat, George
Perlmann, Thomas
Renaud, Jean-Paul
Schwabe, John
Sladek, Frances
Tsai, Ming-Jer
Laudet, Vincent
机构
[1] Ecole Normale Super Lyon, CNRS, INRA 1237, UMR 5161,Lab Biol Mol Cellule,IFR128 BioSci Lyon, F-69364 Lyon 07, France
[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[3] McGill Univ, Ctr Hlth, Mol Oncol Grp, Montreal, PQ, Canada
[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA USA
[5] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
[6] Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia
[7] Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, Stockholm, Sweden
[8] AliX, Illkirch Graffenstaden, France
[9] MRC, Mol Biol Lab, Cambridge, England
[10] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA
关键词
D O I
10.1124/pr.58.4.10
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Half of the members of the nuclear receptors superfamily are so-called "orphan" receptors because the identity of their ligand, if any, is unknown. Because of their important biological roles, the study of orphan receptors has attracted much attention recently and has resulted in rapid advances that have helped in the discovery of novel signaling pathways. In this review we present the main features of orphan receptors, discuss the structure of their ligand-binding domains and their biological functions. The paradoxical existence of a pharmacology of orphan receptors, a rapidly growing and innovative field, is highlighted.
引用
收藏
页码:798 / 836
页数:39
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