Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine

被引：75

作者：

Fagergren, P ^{[1
]}

Hurd, YL ^{[1
]}

机构：

[1] Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden

来源：

NEUROREPORT | 1999年 / 10卷 / 16期

关键词：

central amygdala; gender; in situ hybridization; nucleus accumbens;

D O I：

10.1097/00001756-199911080-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17 beta-estradiol- (30 mu g) and vehicle-treated female rats. A gender difference was noted in the accumbens shell during basal conditions; male rats expressed higher levels of CART mRNA than both female groups. Following binge cocaine; injections (3 x 15 mg/kg), elevated levels were found in the central amygdala of male but not female rats. In the medial accumbens shell CART mRNA was elevated after cocaine, but only in the non-treated females. The present results support a role of mesolimbic CART in psychostimulant drug action. NeuroReport 10:3449-3452 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：3449 / 3452

页数：4

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