Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice

被引：49

作者：

Ritzau, M ^{[1
]}

Heinze, S ^{[1
]}

Dornberger, K ^{[1
]}

Berg, A ^{[1
]}

Fleck, W ^{[1
]}

Schlegel, B ^{[1
]}

Hartl, A ^{[1
]}

Grafe, U ^{[1
]}

机构：

[1] HANS KNOLL INST NAT PROD RES,D-07745 JENA,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 09期

关键词：

D O I：

10.7164/antibiotics.50.722

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.

引用

页码：722 / 728

页数：7