Rapid molecular theranostics in infectious diseases

被引:89
作者
Picard, FJ [1 ]
Bergeron, MG [1 ]
机构
[1] CHU Laval, Ctr Rech Infect, Quebec City, PQ G1V 4G2, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/S1359-6446(02)02497-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The increasing availability of rapid and sensitive nucleic acid testing assays for infectious diseases will revolutionize the practice of medicine by gradually reducing the need for standard culture-based microbiological methods that take at least two days. Molecular theranostics in infectious diseases ' is an emerging concept in which molecular biology tools are used to provide rapid and accurate diagnostic assays to enable better initial management of patients and more efficient use of antimicrobials. Essential conditions and the quality control required for the development and validation of such molecular theranostic assays are reviewed.
引用
收藏
页码:1092 / 1101
页数:10
相关论文
共 84 条
  • [1] [Anonymous], 1999, MANUAL CLIN MICROBIO
  • [2] Antibiotic resistance in Spain: What can be done?
    Baquero, F
    Baraibar, R
    Campos, J
    Dominguez, L
    Garau, J
    GarciaRodriguez, JA
    Guerra, L
    Palau, E
    PerezGorricho, B
    PerezTrallero, E
    Prats, G
    ReyDuran, R
    Bremon, AR
    [J]. CLINICAL INFECTIOUS DISEASES, 1996, 23 (04) : 819 - 823
  • [3] Rapid detection of Shiga toxin-producing bacteria in feces by multiplex PCR with molecular beacons on the smart cycler
    Bélanger, SD
    Boissinot, M
    Ménard, C
    Picard, FJ
    Bergeron, MG
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (04) : 1436 - 1440
  • [4] Infectious disease - PCR detection of bacteria in seven minutes
    Belgrader, P
    Benett, W
    Hadley, D
    Richards, J
    Stratton, P
    Mariella, R
    Milanovich, F
    [J]. SCIENCE, 1999, 284 (5413) : 449 - 450
  • [5] A microfluidic cartridge to prepare spores for PCR analysis
    Belgrader, P
    Okuzumi, M
    Pourahmadi, F
    Borkholder, DA
    Northrup, MA
    [J]. BIOSENSORS & BIOELECTRONICS, 2000, 14 (10-11) : 849 - 852
  • [6] Latent structure analysis of classification errors in screening and clinical diagnosis: An alternative to classification analysis
    Bergan, JR
    Schwarz, RD
    Reddy, LA
    [J]. APPLIED PSYCHOLOGICAL MEASUREMENT, 1999, 23 (01) : 69 - 86
  • [7] Rapid detection of group B streptococci in pregnant women at delivery
    Bergeron, MG
    Ke, DB
    Ménard, C
    Picard, FJ
    Gagnon, M
    Bernier, M
    Ouellette, M
    Roy, PH
    Marcoux, S
    Fraser, WD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (03) : 175 - 179
  • [8] Preventing antibiotic resistance through rapid genotypic identification of bacteria and of their antibiotic resistance genes in the clinical microbiology laboratory
    Bergeron, MG
    Ouellette, M
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (08) : 2169 - 2172
  • [9] BERGERON MG, 2001, MOL TESTING LAB MED, P217
  • [10] Evaluation of recA sequences for identification of Mycobacterium species
    Blackwood, KS
    He, C
    Gunton, J
    Turenne, CY
    Wolfe, J
    Kabani, AM
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (08) : 2846 - 2852