Catalytic Asymmetric Synthesis of 2,2-Disubstituted Oxetanes from Ketones by Using a One-Pot Sequential Addition of Sulfur Ylide

被引：61

作者：

Sone, Toshihiko ^{[1
]}

Lu, Gang ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 09期

关键词：

asymmetric synthesis; homogeneous catalysis; oxetanes; rare-earth metals; ylides; DIMETHYLOXOSULFONIUM METHYLIDE; KINETIC RESOLUTION; SUBSTITUTED OXETANES; EPOXIDE HYDROLASES; ACHIRAL ADDITIVES; COMPLEX; ENONES; POLYMERIZATION; OXIDATION; OLEFINS;

D O I：

10.1002/anie.200805473

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Better the second time around: The title compounds were synthesized by using a one-pot double methylene transfer catalyzed by a heterobimetallic La/Li complex. Chiral amplification in the second step was the key to obtaining oxetanes in high enantiomeric excess (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1677 / 1680

页数：4

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