Memantine augmentation for refractory obsessive-compulsive disorder

被引：75

作者：

Pasquini, Massimo ^{[1
]}

Biondi, Massimo ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Psychiat Sci & Psychol Med, Rome, Italy

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2006年 / 30卷 / 06期

关键词：

glutamatergic transmission; memantine; memory for actions; obsessive-compulsive disorder;

D O I：

10.1016/j.pnpbp.2006.04.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive-compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1173 / 1175

页数：3

共 17 条

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