Regulation and recognization of the extended G-quadruplex by rutin

被引：29

作者：

Sun, Hongxia ^{[1
]}

Xiang, Junfeng ^{[1
]}

Tang, Yalin ^{[1
]}

Xu, Guangzhi ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci,Beijing Natl lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 352卷 / 04期

关键词：

rutin; extended G-quadruplex; blunt-end stacked; interlocked; recognization; regulation;

D O I：

10.1016/j.bbrc.2006.11.125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rutins, a kind of flavonoid glycoside, showed different absorption and fluorescence spectral characteristics when bound to blunt-end stacked and interlocked extended G-quadruplexes. Further H-1 NMR spectra showed these two extended G-quadruplexes bound with rutins in different manners: after binding, the blunt-end stacked extended G-quadruplexes were decomposed to monomers, and the interlocked extended G-quadruplexes did not change. Based on these spectral features, one may expect the usage of rutins in recognizing different structural extended G-quadruplexes and regulating the ratio between blunt-end stacked extended G-quadruplexes and monomers. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：942 / 946

页数：5

共 23 条

[1]

CODY V, 1988, PLANT FLAVONOIDS BIO, V2

[2] An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution [J].