Lymphangiogenic factors, mechanisms, and applications

被引：293

作者：

Zheng, Wei

Aspelund, Aleksanteri

Alitalo, Kari ^{[1
]}

机构：

[1] Univ Helsinki, Wihuri Res Inst, FIN-00014 Helsinki, Finland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 03期

基金：

欧洲研究理事会; 芬兰科学院;

关键词：

GROWTH-FACTOR RECEPTOR-3; LYMPH-NODE METASTASIS; INHIBITS TUMOR-GROWTH; VEGF-C; ENDOTHELIAL-CELLS; INFLAMMATORY LYMPHANGIOGENESIS; PROMOTES LYMPHANGIOGENESIS; GENE-THERAPY; SUPPRESSES LYMPHANGIOGENESIS; VASCULAR MORPHOGENESIS;

D O I：

10.1172/JCI71603

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphed.ema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.

引用

页码：878 / 887

页数：10

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