The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance

被引：39

作者：

Bampi, C ^{[1
]}

Jacquenet, S ^{[1
]}

Lener, D ^{[1
]}

Décimo, D ^{[1
]}

Darlix, JL ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, INSERM 412, LaboRetro, Unite Virol Humaine, F-69364 Lyon, France

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 09期

关键词：

HIV; nucleocapsid protein; nucleic acid chaperone; reverse transcription; genetic variability; proviral DNA maintenance;

D O I：

10.1016/j.biocel.2004.02.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the following three sections, we will briefly review the seminal roles of the HIV-1 nucleocapsid protein p7 (NCp7) in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase (RT) in the course of proviral DNA synthesis and to DNA integrity at the end of the polymerization process, and to the NC-assisted repair and recombination reactions fueling the viability and variability of the virus. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1668 / 1686

页数：19

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