The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance

被引：39

作者：

Bampi, C ^{[1
]}

Jacquenet, S ^{[1
]}

Lener, D ^{[1
]}

Décimo, D ^{[1
]}

Darlix, JL ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, INSERM 412, LaboRetro, Unite Virol Humaine, F-69364 Lyon, France

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 09期

关键词：

HIV; nucleocapsid protein; nucleic acid chaperone; reverse transcription; genetic variability; proviral DNA maintenance;

D O I：

10.1016/j.biocel.2004.02.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the following three sections, we will briefly review the seminal roles of the HIV-1 nucleocapsid protein p7 (NCp7) in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase (RT) in the course of proviral DNA synthesis and to DNA integrity at the end of the polymerization process, and to the NC-assisted repair and recombination reactions fueling the viability and variability of the virus. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1668 / 1686

页数：19

共 156 条

[71] RNA PACKAGING SIGNAL OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

HAYASHI, T ;

SHIODA, T ;

IWAKURA, Y ;

SHIBUTA, H .

VIROLOGY, 1992, 188 (02) :590-599

[72] RNA CHAPERONES AND THE RNA FOLDING PROBLEM [J].

HERSCHLAG, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (36) :20871-20874

[73] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[74] Nucleic acid conformational changes essential for HIV-1 nucleocapsid protein-mediated inhibition of self-priming in minus-strand transfer [J].

Hong, MK ;

Harbron, EJ ;

O'Connor, DB ;

Guo, JH ;

Barbara, PF ;

Levin, JG ;

Musier-Forsyth, K .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (01) :1-10

[75] RETROVIRAL RECOMBINATION AND REVERSE TRANSCRIPTION [J].

HU, WS ;

TEMIN, HM .

SCIENCE, 1990, 250 (4985) :1227-1233

[76] GENETIC CONSEQUENCES OF PACKAGING 2 RNA GENOMES IN ONE RETROVIRAL PARTICLE - PSEUDODIPLOIDY AND HIGH-RATE OF GENETIC-RECOMBINATION [J].

HU, WS ;

TEMIN, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1556-1560

[77] The role of nucleocapsid and U5 stem/A-rich loop sequences in tRNA3Lys genomic placement and initiation of reverse transcription in human immunodeficiency virus type 1 [J].

Huang, Y ;

Khorchid, A ;

Gabor, J ;

Wang, J ;

Li, XG ;

Darlix, JL ;

Wainberg, MA ;

Kleiman, L .

JOURNAL OF VIROLOGY, 1998, 72 (05) :3907-3915

[78] INITIATION OF REVERSE TRANSCRIPTION OF HIV-1 - SECONDARY STRUCTURE OF THE HIV-1 RNA/TRNA(3)(LYS) (TEMPLATE/PRIMER) COMPLEX [J].

ISEL, C ;

EHRESMANN, C ;

KEITH, G ;

EHRESMANN, B ;

MARQUET, R .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 247 (02) :236-250

[79] Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post-transcriptional modifications of primer tRNA(3)(Lys) [J].

Isel, C ;

Lanchy, JM ;

LeGrice, SFJ ;

Ehresmann, C ;

Ehresmann, B ;

Marquet, R .

EMBO JOURNAL, 1996, 15 (04) :917-924

[80] The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly [J].

Javanbakht, H ;

Halwani, R ;

Cen, S ;

Saadatmand, J ;

Musier-Forsyth, K ;

Gottlinger, H ;

Kleiman, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (30) :27644-27651

← 3 4 5 6 7 8 9 10 11 12 →