Interleukin-7 - An interleukin for rejuvenating the immune system

被引：23

作者：

Aspinall, R ^{[1
]}

Henson, S ^{[1
]}

Pido-Lopez, J ^{[1
]}

Ngom, PT ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Immunol, London SW10 9NH, England

来源：

STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE | 2004年 / 1019卷

关键词：

aging; antigen-specific receptor; T cell;

D O I：

10.1196/annals.1297.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 x 10(11). If the individual has not met the virus before, the response will come from the naive T cell subset (50 +/- 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 10(8) per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (alpha and beta), and the repertoire of specificities is somewhere in the region of 2 x 10(7) to 10(8). A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.

引用

页码：116 / 122

页数：7

共 21 条

[1]

IL-7 and not stem cell Factor Reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice [J].

Andrew, D ;

Aspinall, R .

JOURNAL OF IMMUNOLOGY, 2001, 166 (03) :1524-1530

[2]

Aspinall R, 1997, J IMMUNOL, V158, P3037

[3]

Age-associated thymic atrophy is not associated with a deficiency in the CD44+CD25-CD3-CD4-CD8- thymocyte population [J].

Aspinall, R ;

Andrew, D .

CELLULAR IMMUNOLOGY, 2001, 212 (02) :150-157

[4]

DIFFERENTIAL DISPOSITION OF SOLUBLE AND LIPOSOME-FORMULATED HUMAN RECOMBINANT INTERLEUKIN-7 - EFFECTS ON BLOOD LYMPHOCYTE POPULATION IN GUINEA-PIGS [J].

BUI, T ;

FALTYNEK, C ;

HO, RJY .

PHARMACEUTICAL RESEARCH, 1994, 11 (05) :633-641

[5]

The common cytokine receptor γ chain and the pre-T cell receptor provide independent but critically overlapping signals in early α/β T cell development [J].

Di Santo, JP ;

Aifantis, I ;

Rosmaraki, E ;

Garcia, C ;

Feinberg, J ;

Fehling, HJ ;

Fischer, A ;

von Boehmer, H ;

Rocha, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (03) :563-573

[6]

Changes in thymic function with age and during the treatment of HIV infection [J].

Douek, DC ;

McFarland, RD ;

Keiser, PH ;

Gage, EA ;

Massey, JM ;

Haynes, BF ;

Polis, MA ;

Haase, AT ;

Feinberg, MB ;

Sullivan, JL ;

Jamieson, BD ;

Zack, JA ;

Picker, LJ ;

Koup, RA .

NATURE, 1998, 396 (6712) :690-695

[7]

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? [J].

Effros, RB ;

Pawelec, G .

IMMUNOLOGY TODAY, 1997, 18 (09) :450-454

[8]

Interleukin-7: master regulator of peripheral T-cell homeostasis? [J].

Fry, TJ ;

Mackall, CL .

TRENDS IN IMMUNOLOGY, 2001, 22 (10) :564-571

[9]

HOBBS MV, 1993, J IMMUNOL, V150, P3602

[10]

THE ROLE OF THYMUS IN THE AGING OF T-H CELL SUBPOPULATIONS AND AGE-ASSOCIATED ALTERATION OF CYTOKINE PRODUCTION BY THESE CELLS [J].

KURASHIMA, C ;

UTSUYAMA, M ;

KASAI, M ;

ISHIJIMA, SA ;

KONNO, A ;

HIROKAWA, K .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (01) :97-104

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