Reduced number of striatal neurons expressing preprosomatostatin mRNA in rats with oral dyskinesias after long-term haloperidol administration

被引：13

作者：

Andreassen, OA

Finsen, B

Ostergaard, K

West, MJ

Jorgensen, HA

机构：

[1] Univ Bergen, Dept Physiol, N-5009 Bergen, Norway

[2] Odense Univ, Dept Anat & Cell Biol, Odense, Denmark

[3] Univ Aarhus, Dept Neurobiol, DK-8200 Aarhus, Denmark

[4] Univ Bergen, Dept Psychiat, Sandviken Hosp, Bergen, Norway

来源：

NEUROSCIENCE LETTERS | 2000年 / 279卷 / 01期

关键词：

neuroleptics; neuropeptides; stereology; densitometry; vacuous chewing movements; tardive dyskinesia;

D O I：

10.1016/S0304-3940(99)00939-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroleptic-induced oral dyskinesia in rats, a putative analogue to human tardive dyskinesia, may be due to degeneration within the striatum. Using unbiased stereological methods, a decreased number of striatal neurons expressing preprosomatostatin mRNA was observed only in rats that developed pronounced oral dyskinesias after 30 weeks of haloperidol administration. The amount of preprosomatostatin mRNA in each striatal neuron, measured in terms of optical densities of individual neurons, was not affected by haloperidol. A tendency toward a reduction in the number of NADPH-diaphorase positive neurons was observed in rats receiving haloperidol. These results indicate that the mechanism by which neuroleptics induce oral dyskinesias in rats, and perhaps tardive dyskinesia in humans, involves a functional disruption and possibly damage of a subpopulation of interneurons in the striatum. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：21 / 24

页数：4