Re-analysis of collaborative study on the genetics of alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299

被引：6

作者：

Curtis, D

机构：

[1] Academic Department of Psychiatry, Qu. Mary's Sch. of Med. and Dent.

[2] Department of Adult Psychiatry, Royal London Hospital, Whitechapel

来源：

PSYCHIATRIC GENETICS | 2004年 / 14卷 / 03期

关键词：

personality trail; linkage analysis; QMFLINK;

D O I：

10.1097/00041444-200409000-00006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A previous genome scan using variance components analysis of 758 sib pairs from families of alcoholics found evidence for linkage of harm avoidance (HA) to markers on 8p21-23, and this finding was supported in a subsequent linkage study of 384 sib pairs. Here the original dataset is analysed using a new method of linkage analysis for quantitative traits that deals with extended pedigrees. As well as supporting linkage of HA to D8S549, this method also produces an MALOD of 2.4 (P = 0.002) near DBH and several positive lod scores for novelty-seeking, the largest being MALODs of 3.1 (P = 0.0004) near D12S391 and 3.4 (P = 0.0003) near D17S1299. There is no support for linkage of novelty-seeking or HA to the regions around DRD4 and 5HTT, respectively. Additional samples will need to be studied in order to discover which regions truly harbour genetic polymorphisms influencing personality traits. (C) 2004 Lippincott Williams Wilkins.

引用

页码：151 / 155

页数：5

共 19 条

[1]

Begleiter H, 1999, GENET EPIDEMIOL, V17, pS25

[2]

CLONINGER CR, 1987, ARCH GEN PSYCHIAT, V44, P573

[3]

Cloninger CR, 1998, AM J MED GENET, V81, P313, DOI 10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO

[4]

2-U

[5]

Curtis D, 1999, GENET EPIDEMIOL, V17, pS115

[6]

CURTIS D, 1995, AM J HUM GENET, V57, P703

[7]

CURTIS D, 2003, UNPUB NEW METHOD LIN

[8] Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping [J].

Foroud, T ;

Edenberg, HJ ;

Goate, A ;

Rice, J ;

Flury, L ;

Koller, DL ;

Bierut, LJ ;

Conneally, PM ;

Nurnberger, JI ;

Bucholz, KK ;

Li, TK ;

Hesselbrock, V ;

Crowe, R ;

Schuckit, M ;

Porjesz, B ;

Begleiter, H ;

Reich, T .

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2000, 24 (07) :933-945

[9] A meta-analysis of the association between DRD4 polymorphism and novelty seeking [J].

Kluger, AN ;

Siegfried, Z ;

Ebstein, RP .

MOLECULAR PSYCHIATRY, 2002, 7 (07) :712-717

[10] Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait [J].

Knight, J ;

North, BV ;

Sham, PC ;

Curtis, D .

BMC GENETICS, 2003, 4 (Suppl 1)

← 1 2 →