Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators

被引：15

作者：

Bebbington, D ^{[1
]}

Dawson, CE ^{[1
]}

Gaur, S ^{[1
]}

Spencer, J ^{[1
]}

机构：

[1] Vernalis Res Ltd, Dept Chem, Woking RG41 5UA, Surrey, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(02)00698-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Water soluble prodrugs of hybrid free radical scavenger/iron chelating molecules, based on 3,5-disubstituted-4-hydroxyphenyl derivatives and 3-hydroxy-2-methyl-4(1H)-pyridinone (deferiprone), have been prepared. Related hybrid molecules containing a covalent poly(ethylene)glycol or an amine linker were also synthesized. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3297 / 3300

页数：4

共 26 条

[1] 3,5-disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone:: Potent inhibitors of lipid peroxidation and cell toxicity
Bebbington, D
Monck, NJT
Gaur, S
Palmer, AM
Benwell, K
Harvey, V
Malcolm, CS
Porter, RHP
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (15) : 2779 - 2782
[2] Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease
Butterfield, DA
Howard, BJ
LaFontaine, MA
[J]. CURRENT MEDICINAL CHEMISTRY, 2001, 8 (07) : 815 - 828
[3] BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation:: A promising neuroprotective strategy
Chabrier, PE
Auguet, M
Spinnewyn, B
Auvin, S
Cornet, S
Demerlé-Pallardy, C
Guilmard-Favre, C
Marin, JG
Pignol, B
Gillard-Roubert, V
Roussillot-Charnet, C
Schulz, J
Viossat, I
Bigg, D
Moncada, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) : 10824 - 10829
[4] Efficacy of antioxidant therapies in transient focal ischemia in mice
Clark, WM
Rinker, LG
Lessov, NS
Lowery, SL
Cipolla, MJ
[J]. STROKE, 2001, 32 (04) : 1000 - 1004
[5] SYNTHESIS, PHYSICOCHEMICAL PROPERTIES, AND BIOLOGICAL EVALUATION OF N-SUBSTITUTED 2-ALKYL-3-HYDROXY-4(1H)-PYRIDINONES - ORALLY-ACTIVE IRON CHELATORS WITH CLINICAL POTENTIAL
DOBBIN, PS
HIDER, RC
HALL, AD
TAYLOR, PD
SARPONG, P
PORTER, JB
XIAO, GY
VANDERHELM, D
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) : 2448 - 2458
[6] 6,6′-Bis(2-hydroxyphenyl)-2,2′-bipyridine manganese(III) complexes:: A novel series of superoxide dismutase and catalase mimetics
Giblin, GMP
Box, PC
Campbell, IB
Hancock, AP
Roomans, S
Mills, GI
Molloy, C
Tranter, GE
Walker, AL
Doctrow, SR
Huffman, K
Malfroy, B
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (11) : 1367 - 1370
[7] A novel protecting group for hindered phenols
Hansen, MM
Riggs, JR
[J]. TETRAHEDRON LETTERS, 1998, 39 (18) : 2705 - 2706
[8] ANIMAL-MODELS OF ACUTE ISCHEMIC STROKE - CAN THEY PREDICT CLINICALLY SUCCESSFUL NEUROPROTECTIVE DRUGS
HUNTER, AJ
GREEN, AR
CROSS, AJ
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1995, 16 (04) : 123 - 128
[9] Jarrott B, 1999, DRUG DEVELOP RES, V46, P261, DOI 10.1002/(SICI)1098-2299(199903/04)46:3/4<261::AID-DDR11>3.3.CO
[10] 2-H

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