PEG-supported synthesis of pyrazole oligoamides with peptide β-sheet affinity

被引：21

作者：

Cernovská, K

Kemter, M

Gallmeier, HC

Rzepecki, P

Schrader, T ^{[1
]}

König, B

机构：

[1] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany

[2] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 11期

关键词：

D O I：

10.1039/b401968g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.

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页码：1603 / 1611

页数：9

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