Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation

被引：201

作者：

Godec, Jernej ^{[1
,2
]}

Tan, Yan ^{[3
,4
]}

Liberzon, Arthur ^{[3
]}

Tamayo, Pablo ^{[3
]}

Bhattacharya, Sanchita ^{[5
]}

Butte, Atul J. ^{[5
]}

Mesirov, Jill P. ^{[3
,4
]}

Haining, W. Nicholas ^{[1
,3
,6
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[4] Boston Univ, Bioinformat Program, Boston, MA 02215 USA

[5] Univ Calif San Francisco, Inst Computat Hlth Sci, San Francisco, CA 94158 USA

[6] Harvard Univ, Sch Med, Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

来源：

IMMUNITY | 2016年 / 44卷 / 01期

关键词：

CD8(+) T-CELLS; GENE-EXPRESSION; DATABASE; MODELS;

D O I：

10.1016/j.immuni.2015.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improve transcriptional analysis in immunology, we created ImmuneSigDB: a manually annotated compendium of similar to 5,000 gene-sets from diverse cell states, experimental manipulations, and genetic perturbations in immunology. Analysis using ImmuneSigDB identified signatures induced in activated myeloid cells and differentiating lymphocytes that were highly conserved between humans and mice. Sepsis triggered conserved patterns of gene expression in humans and mouse models. However, we also identified species-specific biological processes in the sepsis transcriptional response: although both species upregulated phagocytosis-related genes, a mitosis signature was specific to humans. ImmuneSigDB enables granular analysis of transcriptomic data to improve biological understanding of immune processes of the human and mouse immune systems.

引用

页码：194 / 206

页数：13

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