Preparation of substituted 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines from catalytic Cp*Ir hydrogen transfer N-heterocyclization of anilino alcohols

被引：45

作者：

Eary, C. Todd ^{[1
]}

Clausen, Dane ^{[1
]}

机构：

[1] Array BioPharma, Boulder, CO 80301 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 38期

关键词：

D O I：

10.1016/j.tetlet.2006.07.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The [Cp*IrCl2](2)/K2CO3 catalyzed hydrogen transfer N-heterocyclization on a series of anilino alcohols has been investigated. The catalyst (20% loading) converts anilino alcohols to 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines in 30-84% isolated yield. (c) 2006 Published by Elsevier Ltd.

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页码：6899 / 6902

页数：4

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