FlexServ: an integrated tool for the analysis of protein flexibility

被引：69

作者：

Camps, Jordi ^{[1
,2
,3
]}

Carrillo, Oliver ^{[1
,2
]}

Emperador, Agusti ^{[1
,2
]}

Orellana, Laura ^{[1
,2
]}

Hospital, Adam ^{[1
,2
,3
]}

Rueda, Manuel ^{[1
,2
]}

Cicin-Sain, Damjan ^{[1
,2
,3
]}

D'Abramo, Marco ^{[1
,2
,4
]}

Lluis Gelpi, Josep ^{[1
,2
,3
,4
]}

Orozco, Modesto ^{[1
,2
,3
,4
]}

机构：

[1] Inst Res Biomed, Joint IRB BSC Program Computat Biol, Barcelona 08028, Spain

[2] Barcelona Supercomp Ctr, Barcelona, Spain

[3] Natl Inst Bioinformat, Barcelona 08034, Spain

[4] Univ Barcelona, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain

来源：

BIOINFORMATICS | 2009年 / 25卷 / 13期

关键词：

NORMAL-MODE ANALYSIS; ESSENTIAL DYNAMICS;

D O I：

10.1093/bioinformatics/btp304

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann's indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.

引用

页码：1709 / 1710

页数：2

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