Antigen processing and presentation by intestinal epithelial cells - polarity and complexity

被引：213

作者：

Hershberg, RM ^{[1
]}

Mayer, LF

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

[3] Mt Sinai Sch Med, Ctr Immunobiol, New York, NY 10029 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(99)01575-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg ann colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa.

引用

页码：123 / 128

页数：6

共 54 条

[21] Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
Groh, V
Bahram, S
Bauer, S
Herman, A
Beauchamp, M
Spies, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) : 12445 - 12450
[22] Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells
Groh, V
Steinle, A
Bauer, S
Spies, T
[J]. SCIENCE, 1998, 279 (5357) : 1737 - 1740
[23] EXPRESSION OF THE THYMUS LEUKEMIA ANTIGEN IN MOUSE INTESTINAL EPITHELIUM
HERSHBERG, R
EGHTESADY, P
SYDORA, B
BRORSON, K
CHEROUTRE, H
MODLIN, R
KRONENBERG, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) : 9727 - 9731
[24] Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
Hershberg, RM
Cho, DH
Youakim, A
Bradley, MB
Lee, JS
Framson, PE
Nepom, GT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (04) : 792 - 803
[25] Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing
Hershberg, RM
Framson, PE
Cho, DH
Lee, LY
Kovats, S
Beitz, J
Blum, JS
Nepom, GT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (01) : 204 - 215
[26] IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF HLA-DR ANTIGEN IN CONTROL SMALL-INTESTINE AND COLON AND IN INFLAMMATORY BOWEL-DISEASE
HIRATA, I
AUSTIN, LL
BLACKWELL, WH
WEBER, JR
DOBBINS, WO
[J]. DIGESTIVE DISEASES AND SCIENCES, 1986, 31 (12) : 1317 - 1330
[27] Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice
Hong, SM
Scherer, DC
Singh, N
Mendiratta, SK
Serizawa, I
Koezuka, Y
Van Kaer, L
[J]. IMMUNOLOGICAL REVIEWS, 1999, 169 : 31 - 44
[28] Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM-1) expression and neutrophil adhesion
Huang, GTJ
Eckmann, L
Savidge, TC
Kagnoff, MF
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (02) : 572 - 583
[29] Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells
Israel, EJ
Taylor, S
Wu, Z
Mizoguchi, E
Blumberg, RS
Bhan, A
Simister, NE
[J]. IMMUNOLOGY, 1997, 92 (01) : 69 - 74
[30] JACKMAN MR, 1994, J CELL SCI, V107, P2547

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