MicroRNA as potential biomarker in HCV-associated diffuse large B-cell lymphoma

被引：32

作者：

Augello, Claudia ^{[1
]}

Gianelli, Umberto ^{[2
]}

Savi, Federica ^{[3
]}

Moro, Alessia ^{[3
]}

Bonoldi, Emanuela ^{[4
]}

Gambacorta, Marcello ^{[5
]}

Vaira, Valentina ^{[6
]}

Baldini, Luca ^{[7
]}

Bosari, Silvano ^{[8
]}

机构：

[1] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy

[2] Univ Milan, Div Pathol, Dept Pathophysiol & Transplantat, Hematopathol Serv,IRCCS Ca Granda Maggiore Policl, I-20122 Milan, Italy

[3] San Paolo Hosp, Div Pathol, Milan, Italy

[4] A Manzoni Hosp, Div Pathol, Lecce, Italy

[5] Osped Niguarda Ca Granda, Dept Lab Med, Milan, Italy

[6] IRCCS Ca Granda Maggiore Policlin Hosp Fdn, Div Pathol, Milan, Italy

[7] Univ Milan, Div Hematol, Dept Clin & Community Sci, IRCCS Ca Granda Maggiore Policlin Hosp Fdn, I-20122 Milan, Italy

[8] Univ Milan, Div Pathol, Dept Pathophysiol & Transplantat, IRCCS Ca Granda Maggiore Policlin Hosp Fdn, I-20122 Milan, Italy

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2014年 / 67卷 / 08期

关键词：

HEPATITIS-C VIRUS; EXPRESSION; EPIDEMIOLOGY;

D O I：

10.1136/jclinpath-2014-202352

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aims To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling. Methods In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed according to HCV presence. Germinal centres, from reactive lymph nodes were used as controls. Clinical features at presentation were available for all patients. Results A set of 52 miRNAs define a signature for HCV-associated DLBCL. Importantly, decreased expression of miR-138-5p and increased expression of miR-147a, miR-147b and miR-511-5p in HCV DLBCL was found to be a poor prognostic factor for HCV-positive DLBCL patients. Conclusions These data reveal molecular differences in diffuse DLBCL patients according to HCV presence, potentially useful as novel prognostic or therapeutic biomarkers.

引用

页码：697 / 701

页数：5

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