Circular RNAs in cancer: an emerging key player

被引：277

作者：

Dong, Yeping ^{[1
]}

He, Dan ^{[1
]}

Peng, Zhenzi ^{[1
]}

Peng, Wei ^{[1
]}

Shi, Wenwen ^{[1
]}

Wang, Jun ^{[1
]}

Li, Bin ^{[1
]}

Zhang, Chunfang ^{[2
]}

Duan, Chaojun ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Inst Med Sci, Xiangya Hosp, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Minist Hlth, Key Lab Canc Prote Chinese, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp, Dept Thorac Surg, Xiangya Rd 87th, Changsha 410008, Hunan, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2017年 / 10卷

关键词：

Circular RNAs; Cancer; MicroRNA sponges; Biomarkers; GROWTH-FACTOR RECEPTOR; MESSENGER-RNA; MICRORNA-7; EXPRESSION; BIOMARKER; BIOGENESIS; PATHWAY; TRANSLATION; PLATELETS; REVEALS;

D O I：

10.1186/s13045-016-0370-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers. After miRNA and long noncoding RNA (lncRNA), circRNAs are becoming a new hotspot in the field of RNA of cancer. Here, we review biogenesis and metabolism of circRNAs, their functions, and potential roles in cancer.

引用

收藏

页码：1 / 8

页数：8

相关论文

共 58 条

[1]

Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt [J].

AbouHaidar, Mounir Georges ;

Venkataraman, Srividhya ;

Golshani, Ashkan ;

Liu, Bolin ;

Ahmad, Tauqeer .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (40) :14542-14547

[2]

Circular RNA enrichment in platelets is a signature of transcriptome degradation [J].

Alhasan, Abd A. ;

Izuogu, Osagie G. ;

Al-Balool, Haya H. ;

Steyn, Jannetta S. ;

Evans, Amanda ;

Colzani, Maria ;

Ghevaert, Cedric ;

Mountford, Joanne C. ;

Marenah, Lamin ;

Elliott, David J. ;

Santibanez-Koref, Mauro ;

Jackson, Michael S. .

BLOOD, 2016, 127 (09) :E1-E11

[3]

[Anonymous], EUROPEAN HEART J

[4]

circRNA Biogenesis Competes with Pre-mRNA Splicing [J].

Ashwal-Fluss, Reut ;

Meyer, Markus ;

Pamudurti, Nagarjuna Reddy ;

Ivanov, Andranik ;

Bartok, Osnat ;

Hanan, Mor ;

Evantal, Naveh ;

Memczak, Sebastian ;

Rajewsky, Nikolaus ;

Kadener, Sebastian .

MOLECULAR CELL, 2014, 56 (01) :55-66

[5]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6]

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer [J].

Beale, Gary ;

Haagensen, Emma J. ;

Thomas, Huw D. ;

Wang, Lan-Zhen ;

Revill, Charlotte H. ;

Payne, Sara L. ;

Golding, Bernard T. ;

Hardcastle, Ian R. ;

Newell, David R. ;

Griffin, Roger J. ;

Cano, Celine .

BRITISH JOURNAL OF CANCER, 2016, 115 (06) :682-690

[7]

The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation [J].

Beckedorff, Felipe C. ;

Ayupe, Ana C. ;

Crocci-Souza, Renan ;

Amaral, Murilo S. ;

Nakaya, Helder I. ;

Soltys, Daniela T. ;

Menck, Carlos F. M. ;

Reis, Eduardo M. ;

Verjovski-Almeida, Sergio .

PLOS GENETICS, 2013, 9 (08)

[8]

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics [J].

Best, Myron G. ;

Sol, Nik ;

Kooi, Irsan ;

Tannous, Jihane ;

Westerman, Bart A. ;

Rustenburg, Francois ;

Schellen, Pepijn ;

Verschueren, Heleen ;

Post, Edward ;

Koster, Jan ;

Ylstra, Bauke ;

Ameziane, Najim ;

Dorsman, Josephine ;

Smit, Egbert F. ;

Verheul, Henk M. ;

Noske, David P. ;

Reijneveld, Jaap C. ;

Nilsson, R. Jonas A. ;

Tannous, Bakhos A. ;

Wesseling, Pieter ;

Wurdinger, Thomas .

CANCER CELL, 2015, 28 (05) :666-676

[9]

Cai F, 2016, J CANCER RES CLIN, P1

[10]

INITIATION OF PROTEIN-SYNTHESIS BY THE EUKARYOTIC TRANSLATIONAL APPARATUS ON CIRCULAR RNAS [J].

CHEN, CY ;

SARNOW, P .

SCIENCE, 1995, 268 (5209) :415-417

← 1 2 3 4 5 6 →