The use of carbon paste electrode in the direct voltammetric determination of tryptophan in pharmaceutical formulations

被引:126
作者
Fiorucci, AR [1 ]
Cavalheiro, ÉTG [1 ]
机构
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
关键词
tryptophan; differential pulse voltammetry; carbon paste electrode;
D O I
10.1016/S0731-7085(01)00711-7
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A simple, fast and sensitive method is proposed for Tryptophan (Trp) determination in pharmaceutical formulations containing other non-electroative aminoacids, vitamins and hydroxycobalamines. Optimized conditions for differential pulse voltammetry allowed the determination of Trp with detection limit of 1.7 muM in 2-30 mM linear dynamic range (n = 7; r = 0.999), at a bare, non-treated carbon paste electrode. Ascorbic acid interference was evaluated and eliminated by choosing a suitable baseline for determination of peak currents for Trp. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:909 / 915
页数:7
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