Neurotransmitters and gap junctions in developing neural circuits

被引:118
作者
Roerig, B [1 ]
Feller, MB
机构
[1] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA
[2] NINDS, NIH, Bethesda, MD 20892 USA
关键词
neurotransmitter; gap junction; neural circuit;
D O I
10.1016/S0165-0173(99)00069-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A growing body of evidence suggests that highly correlated, spontaneous neural activity plays an important role in shaping connections in the developing nervous system prior to the maturation of sensory afferents. In this article we discuss the mechanisms involved in the generation and the regulation of spontaneous activity patterns in the developing retina and the developing neocortex. Spontaneous activity in the developing retina propagates across the ganglion cell layer as waves of action potentials and drives rhythmic increases in intracellular calcium in retinal neurons. Retinal waves are mediated by a combination of chemical synaptic transmission and gap junctions, and the circuitry responsible for generating retinal waves changes with age and between species. In the developing cortex, spontaneous calcium elevations propagate across clusters of cortical neurons called domains. Cortical domains are generated by a regenerative mechanism involving second messenger diffusion through gap junctions and subsequent calcium release from internal stores. The neocortical gap junction system is regulated by glutamate-triggered second messenger systems as well as neuromodulatory transmitters, suggesting extensive interactions between synaptic transmission and information flow through gap junctions. The interaction between gap junctions and chemical synaptic transmission observed in these developing networks represent a powerful mechanism by which activity across large groups of neurons can be correlated. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:86 / 114
页数:29
相关论文
共 164 条
[1]   REGULATION OF NITRIC-OXIDE SYNTHASE ACTIVITY IN CORTICAL SLICES BY EXCITATORY AMINO-ACIDS AND CALCIUM [J].
ALAGARSAMY, S ;
LONART, G ;
JOHNSON, KM .
JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 38 (06) :648-653
[2]   The modulation of intercellular coupling in the retina [J].
Baldridge, WH ;
Vaney, DI ;
Weiler, R .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1998, 9 (03) :311-318
[3]  
BAYER EC, 1993, INT REV CYTOL C, V137, P1
[4]   SEROTONIN-1B RECEPTORS IN THE DEVELOPING SOMATOSENSORY AND VISUAL CORTICES ARE LOCATED ON THALAMOCORTICAL AXONS [J].
BENNETTCLARKE, CA ;
LESLIE, MJ ;
CHIAIA, NL ;
RHOADES, RW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :153-157
[5]  
BENNETTCLARKE CA, 1994, J NEUROSCI, V14, P7594
[6]   PATTERNING OF THE NEOCORTICAL PROJECTIONS FROM THE RAPHE NUCLEI IN PERINATAL RATS - INVESTIGATION OF POTENTIAL ORGANIZATIONAL MECHANISMS [J].
BENNETTCLARKE, CA ;
HANKIN, MH ;
LESLIE, MJ ;
CHIAIA, NL ;
RHOADES, RW .
JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 348 (02) :277-290
[7]   DOPAMINERGIC INNERVATION OF THE CEREBRAL-CORTEX - UNEXPECTED DIFFERENCES BETWEEN RODENTS AND PRIMATES [J].
BERGER, B ;
GASPAR, P ;
VERNEY, C .
TRENDS IN NEUROSCIENCES, 1991, 14 (01) :21-27
[8]   NEW DOPAMINERGIC TERMINAL FIELDS IN THE MOTOR, VISUAL (AREA 18B) AND RETROSPLENIAL CORTEX IN THE YOUNG AND ADULT-RAT - IMMUNOCYTOCHEMICAL AND CATECHOLAMINE HISTOCHEMICAL ANALYSES [J].
BERGER, B ;
VERNEY, C ;
ALVAREZ, C ;
VIGNY, A ;
HELLE, KB .
NEUROSCIENCE, 1985, 15 (04) :983-998
[9]   Neuronal calcium signaling [J].
Berridge, MJ .
NEURON, 1998, 21 (01) :13-26
[10]   REDUCTION OF ELECTRICAL COUPLING BETWEEN NECTURUS TASTE RECEPTOR-CELLS, A POSSIBLE ROLE IN ACID TASTE [J].
BIGIANI, A ;
ROPER, SD .
NEUROSCIENCE LETTERS, 1994, 176 (02) :212-216