Chemical Approaches to Stem Cell Biology and Therapeutics

被引：159

作者：

Li, Wenlin ^{[1
]}

Li, Ke ^{[2
]}

Wei, Wanguo ^{[3
]}

Ding, Sheng ^{[2
]}

机构：

[1] Second Mil Med Univ, Dept Cell Biol, Shanghai 200433, Peoples R China

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[3] Chinese Acad Sci, Shanghai Adv Res Inst, Stem Cell & Regenerat Med Ctr, Shanghai 201210, Peoples R China

来源：

CELL STEM CELL | 2013年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SMALL-MOLECULE INHIBITOR; PLUS G-CSF; HEMATOPOIETIC STEM; HUMAN FIBROBLASTS; SELF-RENEWAL; MOUSE FIBROBLASTS; DIRECT CONVERSION; SOMATIC-CELLS; FUNCTIONAL-NEURONS; PROGENITOR CELLS;

D O I：

10.1016/j.stem.2013.08.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine.

引用

页码：270 / 283

页数：14

共 117 条

[31] Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells [J].

Gonzalez, Rodolfo ;

Lee, Jae Wook ;

Schultz, Peter G. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (47) :11181-11185

[32] Klf4 reverts developmentally programmed restriction of ground state pluripotency [J].

Guo, Ge ;

Yang, Jian ;

Nichols, Jennifer ;

Hall, John Simon ;

Eyres, Isobel ;

Mansfield, William ;

Smith, Austin .

DEVELOPMENT, 2009, 136 (07) :1063-1069

[33] Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors [J].

Han, Dong Wook ;

Tapia, Natalia ;

Hermann, Andreas ;

Hemmer, Kathrin ;

Hoeing, Susanne ;

Arauzo-Bravo, Marcos J. ;

Zaehres, Holm ;

Wu, Guangming ;

Frank, Stefan ;

Moritz, Soeren ;

Greber, Boris ;

Yang, Ji Hun ;

Lee, Hoon Taek ;

Schwamborn, Jens C. ;

Storch, Alexander ;

Schoeler, Hans R. .

CELL STEM CELL, 2012, 10 (04) :465-472

[34] Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs [J].

Hanna, Jacob ;

Cheng, Albert W. ;

Saha, Krishanu ;

Kim, Jongpil ;

Lengner, Christopher J. ;

Soldner, Frank ;

Cassady, John P. ;

Muffat, Julien ;

Carey, Bryce W. ;

Jaenisch, Rudolf .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (20) :9222-9227

[35] Metastable Pluripotent States in NOD-Mouse-Derived ESCs [J].

Hanna, Jacob ;

Markoulaki, Styliani ;

Mitalipova, Maisam ;

Cheng, Albert W. ;

Cassady, John P. ;

Staerk, Judith ;

Carey, Bryce W. ;

Lengner, Christopher J. ;

Foreman, Ruth ;

Love, Jennifer ;

Gao, Qing ;

Kim, Jongpil ;

Jaenisch, Rudolf .

CELL STEM CELL, 2009, 4 (06) :513-524

[36] Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein [J].

He, Ling ;

Sabet, Amin ;

Djedjos, Stephen ;

Miller, Ryan ;

Sun, Xiaojian ;

Hussain, Mehboob A. ;

Radovick, Sally ;

Wondisford, Fredric E. .

CELL, 2009, 137 (04) :635-646

[37] The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells [J].

Heng, Jian-Chien Dominic ;

Feng, Bo ;

Han, Jianyong ;

Jiang, Jianming ;

Kraus, Petra ;

Ng, Jia-Hui ;

Orlov, Yuriy L. ;

Huss, Mikael ;

Yang, Lin ;

Lufkin, Thomas ;

Lim, Bing ;

Ng, Huck-Hui .

CELL STEM CELL, 2010, 6 (02) :167-174

[38] Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds [J].

Hou, Pingping ;

Li, Yanqin ;

Zhang, Xu ;

Liu, Chun ;

Guan, Jingyang ;

Li, Honggang ;

Zhao, Ting ;

Ye, Junqing ;

Yang, Weifeng ;

Liu, Kang ;

Ge, Jian ;

Xu, Jun ;

Zhang, Qiang ;

Zhao, Yang ;

Deng, Hongkui .

SCIENCE, 2013, 341 (6146) :651-654

[39] Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors [J].

Huang, Pengyu ;

He, Zhiying ;

Ji, Shuyi ;

Sun, Huawang ;

Xiang, Dao ;

Liu, Changcheng ;

Hu, Yiping ;

Wang, Xin ;

Hui, Lijian .

NATURE, 2011, 475 (7356) :386-U142

[40] In Vivo Differentiation Potential of Epiblast Stem Cells Revealed by Chimeric Embryo Formation [J].

Huang, Yali ;

Osorno, Rodrigo ;

Tsakiridis, Anestis ;

Wilson, Valerie .

CELL REPORTS, 2012, 2 (06) :1571-1578

← 1 2 3 4 5 6 7 8 9 10 →