Ethnic differences in in vitro glyceride synthesis in subcutaneous and omental adipose tissue

被引:18
作者
Bower, JF
Vadlamudi, S
Barakat, HA
机构
[1] E Carolina Univ, Sch Med, Dept Biochem, Greenville, NC 27834 USA
[2] E Carolina Univ, Sch Med, Dept Microbiol & Immunol, Greenville, NC 27834 USA
[3] IBM Corp, Life Sci, Res Triangle Pk, NC 27709 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2002年 / 283卷 / 05期
关键词
triglyceride synthesis; obesity and ethnicity;
D O I
10.1152/ajpendo.00225.2002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Considerable evidence suggests that there are ethnic differences in lipid metabolism between African American and Caucasian women, which may result in increased synthesis of fat in adipose tissue. The purpose of this study was to measure the in vitro rates of [C-14] glucose incorporation into the glyceride-glycerol backbone of triglycerides (TG) and diglycerides (DG) in abdominal subcutaneous (SAT) and omental adipose tissue (OAT). Morbidly obese [African American (n = 15): body mass index (BMI) = 45 +/- 2.3; Caucasian (n = 18): BMI = 51 +/- 2.3] and preobese [African American (n = 7): BMI = 27 +/- 1.0; Caucasian (n = 7): BMI = 25 +/- 1.0] women were examined in this study. There were no significant differences in the rates of synthesis of either TG or DG in SAT of either preobese or obese women. On the other hand, both preobese and obese African American women had higher rates of synthesis of TG in OAT compared with their Caucasian counterparts. This increase in TG synthesis in OAT was not due to differences in cell size or rates of reesterification. Thus African American woman have an increased capacity to synthesize TG in OAT compared with Caucasian women, which may contribute to the higher prevalence of obesity in African American women.
引用
收藏
页码:E988 / E993
页数:6
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