The emergence of the Middle East Respiratory Syndrome coronavirus

被引:72
作者
Milne-Price, Shauna [1 ]
Miazgowicz, Kerri L. [1 ]
Munster, Vincent J. [1 ]
机构
[1] NIAID, Div Intramural Res, Virol Lab, NIH, Hamilton, MT 59840 USA
来源
PATHOGENS AND DISEASE | 2014年 / 71卷 / 02期
基金
美国国家卫生研究院;
关键词
MERS-CoV; coronavirus; epidemiology; molecular biology; intervention strategies; RECEPTOR-BINDING DOMAIN; PIPISTRELLUS BAT CORONAVIRUS; DIPEPTIDYL-PEPTIDASE-IV; GROUP C BETACORONAVIRUS; MERS-COV; SPIKE PROTEIN; SAUDI-ARABIA; SARS-CORONAVIRUS; CLINICAL-FEATURES; CRYSTAL-STRUCTURE;
D O I
10.1111/2049-632X.12166
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
On September 20, 2012, a Saudi Arabian physician reported the isolation of a novel coronavirus from a patient with pneumonia on ProMED-mail. Within a few days, the same virus was detected in a Qatari patient receiving intensive care in a London hospital, a situation reminiscent of the role air travel played in the spread of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. SARS-CoV originated in China's Guangdong Province and affected more than 8000 patients in 26 countries before it was contained 6 months later. Over a year after the emergence of this novel coronavirus - Middle East respiratory syndrome coronavirus (MERS-CoV) - it has caused 178 laboratory-confirmed cases and 76 deaths. The emergence of a second highly pathogenic coronavirus within a decade highlights the importance of a coordinated global response incorporating reservoir surveillance, high-containment capacity with fundamental and applied research programs, and dependable communication pathways to ensure outbreak containment. Here, we review the current state of knowledge on the epidemiology, ecology, molecular biology, clinical features, and intervention strategies of the novel coronavirus, MERS-CoV.
引用
收藏
页码:119 / 134
页数:16
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