A review on fabricating tissue scaffolds using vat photopolymerization

被引:188
作者
Chartrain, Nicholas A. [1 ,2 ,3 ]
Williams, Christopher B. [1 ,2 ,3 ]
Whittington, Abby R. [1 ,3 ,4 ]
机构
[1] Virginia Tech, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA
[2] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA
[3] Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USA
[4] Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA
关键词
3D printing; Stereolithography; Tissue engineering; Tissue scaffolds; Photopolymers; Regenerative medicine; 3D CELL-CULTURE; MICRO-STEREOLITHOGRAPHY; FREEFORM FABRICATION; 3-DIMENSIONAL SCAFFOLDS; ENGINEERING SCAFFOLDS; MECHANICAL-PROPERTIES; CERAMIC STEREOLITHOGRAPHY; BIODEGRADABLE SCAFFOLDS; 2-PHOTON POLYMERIZATION; PHASE-SEPARATION;
D O I
10.1016/j.actbio.2018.05.010
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
Vat Photopolymerization (stereolithography, SLA), an Additive Manufacturing (AM) or 3D printing technology, holds particular promise for the fabrication of tissue scaffolds for use in regenerative medicine. Unlike traditional tissue scaffold fabrication techniques, SLA is capable of fabricating designed scaffolds through the selective photopolymerization of a photopolymer resin on the micron scale. SLA offers unprecedented control over scaffold porosity and permeability, as well as pore size, shape, and interconnectivity. Perhaps even more significantly, SLA can be used to fabricate vascular networks that may encourage angio and vasculogenesis. Fulfilling this potential requires the development of new photopolymers, the incorporation of biochemical factors into printed scaffolds, and an understanding of the effects scaffold geometry have on cell viability, proliferation, and differentiation. This review compares SLA to other scaffold fabrication techniques, highlights significant advances in the field, and offers a perspective on the field's challenges and future directions. Statement of Significance Engineering de novo tissues continues to be challenging due, in part, to our inability to fabricate complex tissue scaffolds that can support cell proliferation and encourage the formation of developed tissue. The goal of this review is to first introduce the reader to traditional and Additive Manufacturing scaffold fabrication techniques. The bulk of this review will then focus on apprising the reader of current research and provide a perspective on the promising use of vat photopolymerization (stereolithography, SLA) for the fabrication of complex tissue scaffolds. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:90 / 111
页数:22
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